Around 825,600 people have died in the United States from Covid-19 since early 2020, data showed, with the latest wave of hospitalisations driven by those not vaccinated.
US health experts have urged Americans to prepare for severe disruptions in coming weeks as the rising wave of Covid-19 cases led by the Omicron variant threatened hospitals, schools and other sectors impacting their daily lives.
Thursday's warning came as the United States reached a record high in Covid-19 cases, while federal officials issued more travel warnings and reportedly prepared to authorise booster shots for 12 to 15-year-olds next week.
For the second day in a row, the United States had a record number of new reported cases based on the seven-day average, with more than 290,000 new infections reported each day, a Reuters news agency tally showed.
At least 18 states and Puerto Rico have set pandemic records for new cases, according to the tally. Maryland, Ohio and Washington, DC, also saw record hospitalisations as overall US Covid-19 hospitalisations rose 27 percent.
The surge comes amid increased holiday travel, with New Year's celebrations still to come, and as schools grapple with students' return to classrooms following winter breaks.
"We are going to see the number of cases in this country rise so dramatically, we are going to have a hard time keeping everyday life operating," Dr. Michael Osterholm, an infectious disease expert at the University of Minnesota, told MSNBC.
"The next month is going to be a viral blizzard," he said. "All of society is going to be pressured by this."
Dr. Anthony Fauci, the nation's top infectious disease official, on Wednesday said cases will likely rise throughout January.
He and other US health officials have said early data show Omicron appears less severe but have continued to push vaccinations, masks and physical distancing. The Centers for Disease Control and Prevention (CDC) also issued new guidelines shortening isolation and quarantine periods, which have been criticized by some disease experts and health care workers.
READ MORE: Omicron replaces Delta to become dominant Covid version in US
Rising hospitalisations
US health regulators planned to approve a third vaccine dose for 12 to 15-year-olds next week, according to media reports. Boosters are already approved for those 16 and older.
With testing shortages and breakthrough cases, experts warn the surge will still upend hospitals, emergency response services, schools and retailers, among others, in coming weeks.
"We have to be really careful about being too dismissive of Omicron," Dr. Peter Hotez, an infectious disease expert at Baylor College of Medicine, told CNN.
Rising hospitalisations as healthcare workers are sidelined with Covid-19 themselves is also concerning, as are fewer effective therapeutics, Hotez said. "We're in for a pretty serious time."
Already, 825,663 people have died in the United States from Covid-19 since early 2020, data showed, with the latest wave of hospitalizations driven by those not vaccinated.
President Joe Biden this month announced new plans to combat Omicron, including federal reinforcements for hospitals and more tests. But some experts have said it is too little, too late.
So far, however, the economy appears steady even as some economists express caution, with US stocks scoring record highs on Thursday.
While airline travel has been widely disrupted and some hard-hit areas have seen shuttered businesses and canceled events, other measures of activity - such as holiday sales - have held up.
The labor market also is holding its ground. New claims for state unemployment benefits fell last week to their lowest level of the pandemic, the Labor Department said on Thursday.
READ MORE: US Covid deaths reach 800,000, infections top 50 million
Impact on education system
Cruise operators took a hit on Thursday, however, after the CDC warned people to avoid them amid a growing number of outbreaks onboard.
How schools handle the surge also looms, with systems in Washington and New York vowing to stay open with more testing.
"We can't shut down our city again," New York City Mayor-elect Eric Adams said on Thursday, unveiling his plan to fight Covid-19 while keeping the country's most populous city open for business.
US Education Secretary Miguel Cardona acknowledged staffing woes but urged schools to keep kids in classrooms.
Unlike last year's shutdowns, "we have better tools now. They should remain open," he told MSNBC, adding that federal funds remain available to bolster staffing and testing.
Randi Weingarten, head of the American Federation of Teachers union, separately told MSNBC schools should remain open but some areas may be unable to do so and need remote options.
Some US colleges have already shifted their next semester to online or delayed in-person return.
Things should thaw after January, as testing shortages ease and recently-approved medicines become more widely available, experts said.
READ MORE: Top health official: US 'failing' in fight to keep Covid in check
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